Key Features

      Siped®AH-8 is a solution of acetyl hexapeptide-8.  It reduces the appearance of dynamic wrinkles caused by  of the muscle contraction,  especially on the forehead and around the eyes. Siped®AH-8 is a safer, cheaper, and milder alternative to Botulinum Toxin.

INCI     P Glycerin - Water (Aqua) - Butylene Glycol - Acetyl Hexapeptide-8

CAS     616204-22-9

Sequence     Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

Properties

     Siped®AH-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle cannot dock and release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.  

Formulation Tips

1  incorporated in cosmetic formula at room temperature.

2  can be compatible with carbomer